The structure of this
molecule was solved at RapiData2007 by Priscila Giuseppe from the
group of Beatriz Guimaraes at the LNLS (Brazilian Synchrotron
Light Laboratory -- http://www.lnls.br/
). The profile of a fish comes from the fertile imagination of
PXRR scientists, and has no actual bearing on the source or function
of this beautiful protein.
P. Giuseppe
Determination of the
3D structure of the leptospiral protein LIC10793
Giuseppe, P.O. and
Guimaraes, B.G.
Laboratorio Nacional de Luz
Sincrotron (LNLS) - Campinas SP Brazil
The
leptospiral protein LIC10793 is a surface antigen of the bacteria
Leptospira interrogans, the causal agent of Leptospirosis.
Recent studies showed that LIC10793 is located at the bacterial outer
membrane and is recognized by antibodies present in sera from early
and convalescent phases of leptospirosis patients (1). This evidence
suggests that LIC10793 may be involved in host-pathogen interactions
and consequently might be valuable for serodiagnosis of both phases
of leptospirosis. Since this protein does not have any close sequence
similarity to proteins of known function, we are using the atomic
resolution structure to search for functional clues.
Identification of a novel potential antigen for early-phase
serodiagnosis of leptospirosis.
1. Arch Microbiol. 2007;188(5):523-32.