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Collected at
2009

Abendroth J,   Staker B,   Robinson H,   Buchko G.W,   Hewitt SN,   Napuli AJ,   Van Voorhis W,   Stacy R,   Myler P,   Stewart L.
Crystal structure of adenylate kinase from burkholderia pseudomallei
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
To be Published
PDB file 3GMT


Bera AK, Atanasova V, Robinson H, Eisenstein E, Coleman JP, Pesci EC, Parsons JF.
Structure of PqsD, a Pseudomonas Quinolone Signal Biosynthetic Enzyme, in Complex with Anthranilate.
Biochemistry. 2009 Aug 20.
Medline Abstract PDB files 3HGU 3HGV  3H76 3H77 and  3H78

Bernhards RC, Jing X, Vogelaar NJ, Robinson H, Schubot FD.
Structural evidence suggests that antiactivator ExsD from Pseudomonas aeruginosa is a DNA binding protein.
Protein Sci. 18 503-13 (2009).

Medline Abstract PDB file 3FD9

Brandão TA, Robinson H, Johnson SJ, Hengge AC.
Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures.
J Am Chem Soc. 131 778-86 (2009).
Medline Abstract  PDB files 3F99, 3F9A and  3F9B

Buchko GW, Robinson H, Addlagatta A.
Structural characterization of the protein cce_0567 from Cyanothece 51142, a metalloprotein associated with nitrogen fixation in the DUF683 family.
Biochim Biophys Acta. 1794 627-33 (2009).
Medline Abstract PDB file 3CSX


Han Q, Robinson H, Cai T, Tagle DA, Li J.
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.
J Med Chem. 52 2786-93 (2009).
Medline Abstract  PDB files 3FVX,3FVU and 3FVS



Honda M, Wang R, Kong WP, Kanekiyo M, Akahata W, Xu L, Matsuo K, Natarajan K, Robinson H, Asher TE, Price DA, Douek DC, Margulies DH, Nabel GJ.
Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity.
J Immunol. 183(4)  2425-34 (2009).
Medline Abstract  PDB files 3E6H and 3E6F


Latimer R, Podzelinska K, Soares A, Bhattacharya A, Vining LC, Jia Z, and Zechel DL.
Expression, purification and preliminary diffraction studies of CmlS.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 65 260-3.(2009).
Medline Abstract 

Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, and Mariuzza RA.
Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.
EMBO J.  28 286-97 (2009).
Medline Abstract  PDB file3D34


Gallagher DT, Smith N, Kim SK, Robinson H, Reddy PT.
Profound asymmetry in the structure of the cAMP-free cAMP receptor protein (CRP) from mycobacterium tuberculosis.
J Biol Chem. 284 8228-32.(2009).
Medline Abstract  PDB file3D0S


Marshall NM, Garner DK, Wilson TD, Gao YG, Robinson H, Nilges MJ, Lu Y.
Rationally tuning the reduction potential of a single cupredoxin beyond the natural range.
Nature 462 113-6 (2009).
Medline Abstract  PDB file 3IN0
X29
Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ.
The Fas-FADD death domain complex structure unravels signalling by receptor clustering.
Nature  457 1019-22 (2009).
Medline Abstract  PDB file 3EZQ


Stadtmueller BM, Ferrell K, Whitby FG, Heroux A, Robinson H, Myszka DG, Hill CP.
Structural models for interactions between the 20S proteasome and its PAN/19S activators.
J Biol Chem. 2009 Nov 4. [Epub ahead of print]
Medline Abstract  PDB files 3JRM  3JSE and 3JTL




Woo JS, Lim JH, Shin HC, Suh MK, Ku B, Lee KH, Joo K, Robinson H, Lee J, Park SY, Ha NC, Oh BH.
Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions.
Cell. 136 85-96 (2009).
Medline Abstract  PDB files 3EUJ and 3EUH

Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Beek EV, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E.
Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation.
J Am Chem Soc. 31 5153-62 (2009).
Medline Abstract  PDB files   2OPM 3DYJ 3DYF  and  3EF


Zhao H, Heroux A, Sequeira RD, Tang L.
Preliminary crystallographic studies of the regulatory domain of response regulator YycF from an essential two-component signal transduction system.
Acta Crystallogr  F65 719-722 (2009).
Medline Abstract

2008

Altman MD, Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Chellappan S, Kairys V, Fernandes MX, Gilson MK, Schiffer CA, Rana TM, Tidor B.
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
J Am Chem Soc. 130 6099-113  (2008) .
Medline Abstract  PDB file 2Qi7

Bowley SR, Merenbloom BK, Okumura N, Betts L, Heroux A, Gorkun OV and Lord ST.
Polymerization-Defective Fibrinogen Variant gammaD364A Binds Knob "A" Peptide Mimic.
Biochemistry 105 3817-22 (2008).
Medline Abstract  PDB file 3BVH

Buchko GW, Robinson H, Pakrasi HB and Kennedy MA.
Insights into the structural variation between pentapeptide repeat proteins-Crystal structure of Rfr23 from Cyanothece 51142.
J. Struct. Biol.  162 184-92 (2008).
Medline Abstract  PDB file 2O6W

Buchko GW, Litvinova O, Robinson H, Yakunin AF and Kennedy MA.
Functional and Structural Characterization of DR_0079 from Deinococcus radiodurans, a Novel Nudix Hydrolase with a Preference for Cytosine (Deoxy)ribonucleoside 5'-Di- and Triphosphates.
Biochemistry 47 6571-82 (2008).
 Medline Abstract PDB file 2O5F

Chen G, Wang H, Robinson H, Cai J, Wan Y and Ke H.
An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies.
Biochem Pharmacol. 751717-28 (2008).
Medline Abstract PDB files 3BJC

Garst AD, Héroux A, Rambo RP, and Batey RT.
Crystal structure of the lysine riboswitch regulatory mRNA element.
J Biol Chem. 283(33) 22347-51 (2008).
Medline Abstract PDB files 3D0U and 3D0X

Greenhagen BT, Shi K, Robinson H, Gamage S, Bera AK, Ladner JE and Parsons JF.
Crystal Structure of the Pyocyanin Biosynthetic Protein PhzS.
Biochemistry. 47 5281-9 (2008).
Medline Abstract PDB file 2RGJ


Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP.
Biochemical and structural studies of yeast Vps4 oligomerization.
J Mol Biol. 384 878-95  (2008).
Medline Abstract PDB files 3EIE  and  3EIH

Hall BM, Roberts SA, Heroux A and Cordes M.
Two structures of a λ Cro variant highlight dimer flexibility but disfavor major dimer distortions upon binding of cognate DNA.
J. Mol.Biol. 375 802-11 (2008).
Medline Abstract PDB files 2OVG and  2ECS

Han Q,  Robinson H, and Li J.
Crystal structure of human kynurenine aminotransferase II.
J Biol Chem. 283 3567-73 (2008)
Medline Abstract PDB files 2R2N and  2QLR


Han Q,  Robinson H, Cai T, Tagle DA, and Li J.
Biochemical and structural properties of mouse KAT III.
Mol Cell Biol.. (2008)
Medline Abstract PDB files 3E2F , 3E2Y ,and  3E2Z

Han Q, Cai T, Tagle DA, Robinson H,  and Li J.
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II.
Biosci Rep. 28(4) 205-15 (2008).
Medline Abstract PDB file 3DC1

Han Q, Gao YG, Robinson H, and Li J.
Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase.
Biochemistry 47 1622-30 (2008) epub
Medline Abstract PDB file 2R5E and  2R5C

Johnson SJ, Close D, Robinson H, Vallet-Gely I, Dove SL and Hill CP.
Crystal Structure and RNA Binding of the Tex Protein from Pseudomonas aeruginosa.
J. Mol. Biol. 377 1460-73 (2008).
Medline Abstract PDB files 3BZC and  3BZK

Kim SK, Reddy SK, Nelson BC, Robinson H, Reddy PT, Ladner JE.
A comparative biochemical and structural analysis of the intracellular chorismate mutase (Rv0948c) from Mycobacterium tuberculosis HR and the secreted chorismate mutase (y2828) from Yersinia pestis.
FEBS J. 275 4824-35 (2008 ).
.Medline Abstract; PDB file 2QBV


Lee J, Dubey VK, Longo LM, Blaber M.
A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif.
J Mol. Biol. 377 1251-64 (2008).
Medline Abstract PDB files 3B9U , 3BA5, 3BAD, 3BAG, 3BAQ,and  3BAV

Pallana PS, Ittig D, Héroux A, Wawrzak Z, Leumann CJ and Egli M.
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
Chem. Commun. (Camb).  7 883-5 (2008).
.Medline Abstract;PDB file 2RF3

Petrie EJ, Clements CS, Lin J, Sullivan LC, Johnson D, Huyton T, Heroux A, Hoare HL, Beddoe T, Reid HH, Wilce MC, Brooks AG, and Rossjohn J.
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.
J. Exp. Med. 205 725-35 (2008).
Medline Abstract; PDB file 3CDG


Podzelinska K, He S, Soares A, Zechel D, Hove-Jensen B and  Jia Z.
Expression, purification and preliminary diffraction studies of PhnP.
Acta Cryst.  F64, 554-557 (2008).
[ doi:10.1107/S1744309108014656 ]

Salameh MA, Soares AS, Hockla A, Radisky ES.
Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin.
J. Biol. Chem. 283 4115-23 (2008).
Medline Abstract; PDB files 2RA3   and  2R9P

Schubert HL, Phillips JD, Heroux A, Hill CP.
Structure and Mechanistic Implications of a Uroporphyrinogen III Synthase-Product Complex.
Biochemistry. 47 8648-55 (2008).
 Medline Abstract; PDB files 3D8N, 3D8R, 3D8S and  3D8T

Spoonamore JE, Roberts SA,  Heroux A and Bandaria V.
Structure of a 6-pyruvoyltetrahydropterin synthase homolog from Streptomyces coelicolor.
Acta Cryst.  F64, 875-879 (2008).

 Medline Abstract; PDB file 3D7J

Vandemark AP, Xin H, McCullough L, Rawlins R, Bentley S, Heroux A, Stillman DJ, Hill CP andFormosa T.
Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits.
J Biol Chem. 283 5058-68 (2008).
Medline Abstract ; PDB files 3BIT and  3ECN


Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H.
Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity.
Biochemistry (2008) Nov 5.
Medline Abstract ; PDB files 3ECM , 3BIQ and  3BIP

Wang H, Ye M, Robinson H, Francis SH, Ke H.
Conformational variations of both PDE5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol Pharmacol. 73 104-110   (2008).
Medline Abstract; PDB file  3B2R

Wingard JN, Ladner J, Vanarotti M, Fisher A, Robinson H, Buchanan KT, Engman DM, Ames JB.
Structural insights into membrane-targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Tryponosoma cruzi.
J. Biol. Chem. 283(34) 23388-96 (2008) .
Medline Abstract; PDB file 3CS1

Yang K, Zhang L, Xu T, Heroux A, Zhao R.
Crystal structure of the {beta}-finger domain of Prp8 reveals analogy to ribosomal proteins.
Proc Natl Acad Sci U S A. 105 13817-22 (2008).
Medline Abstract ; PDB file 3E66

Zhao X, Copeland DM, Soares AS, and West AH.
Crystal Structure of a Complex between the Phosphorelay Protein YPD1 and the Response Regulator Domain of SLN1 Bound to a Phosphoryl Analog.
J. M. Biol  375 1141-51(2008).
Medline Abstract; PDB file 2R25

2007
X29

Amoia AM, and Monfort WR.
Apo-nitrophorin 4 at atomic resolution
Protein Science 16 2076-2081 (2007).
 Medline Abstract; PDB file 2OFM
X12C
X29


Carra JH, McHugh CA, Mulligan S, Machiesky LM, Soares AS and Millard CB.
Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site.
BMC Struct. Biol.  7 72 (2007).
Medline Abstract PDB files 2PJO, 2PJN, 2R2X, 2R3D and  2P8N

Eoff RL, Angel KC, Egli M, Guengerich FP.
Molecular Basis of Selectivity of Nucleoside Triphosphate Incorporation
Opposite O6-Benzylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4STEADY-STATE AND PRE-STEADY-STATE KINETICS AND X-RAY CRYSTALLOGRAPHY OF CORRECT AND INCORRECT PAIRING
J. Biol. Chem., 282, 13573-13584 ( 2007).
Medline Abstract PDB files 2JEI
X29
Fisher RD, Chung HY, Zhai Q, Robinson H,Sundquist WI and Hill CP.
Structural and Biochemical Studies of ALIX/AIP1 and Its Role inRetrovirus Budding.
Cell  128 841-52 (2007).
Medline Abstract PDB files 2OEX, 2OEV and  2EOW
X29
Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M.
Structure and Activity of Y-class DNA Polymerase DPO4 from Sulfolobus solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene
J. Biol. Chem., 282, 36421-36433 (2007)
Medline Abstract PDB files 2VA3,
X29

Keiski CL, Yip P, Robinson H, Burrows LL, Howell PL.
Expression, purification, crystallization and preliminary X-ray analysis of Pseudomonas fluorescens AlgK.
Acta Cryst.  F63  415-8 (2007) .
Medline Abstract

Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP.
Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein.
J. Mol Biol. 373, 355-366 (2007).
Medline Abstract PDB files  2PRX , 2JPR 2PWO and  2PWM
X29
Kim SK, Robinson H,  Nelson BC, Ready PT and Ladner JE
Crystal Structure of Yersinia pestis Chorismate Mutase
To be Published

Medline Abstract PDB file 2GBB
X29,X12B
Kvansakul M, van Delft M, Lee E, Gulbis J, Fairlie W, D Huang and P Colman.
 A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
 Mol. Cell 25  933-942 (2007).
Medline Abstract PDB files 2JBX and  2JBY
X12B
Hewitson KS, Liénard BM, McDonough MA, Clifton I, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ.
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates.
J Biol Chem. 282 3293 (2007).
Medline Abstract; PDB files 2CGO and 2CGN

Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH.
Cellular expression and crystal structure of the murine cytomegalovirus MHC-Iv glycoprotein, m153.
J Biol Chem.  282 35247-58 (2007).
Medline Abstract; PDB file 2O5N

X29
Moore BA, Robinson HH and  Xu Z.
The Crystal Structure of Mouse Exo70 Reveals Unique Features of the Mammalian Exocyst.
J Mol Biol. 371 1141-50 (2007).
Medline Abstract; PDB file 2PFV
X29
Oruganti S, Zhang Y, Li H, Robinson H, Terns MP, Terns RM, Yang W, Li H.
Alternative Conformations of the Archaeal Nop56/58-Fibrillarin Complex Imply Flexibility in Box C/D RNPs.
J Mol Biol.  371 1141-50 (2007).
Medline Abstract; PDB file 2NNW
X29
Parson JF, Greenhagen BT, Shi K, Calabrese K, Robinson H, Ladner JE.
Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa.
Biochemistry  46 1821-8 (2007).
Medline Abstract; PDB file 2IP2
X29
Pfister TD, Mirareli AY, Gengenbach AJ, Zhaoi X, Danstrom C, Conaster N, Gao YG, Robinson H, Zukoski CF, Wang AH and LuY.
Kinetic and crystallographic studies of a redesigned manganese-binding site in cytochrome c peroxidase.
J Biol Inorg Chem. 1 126-37 (2007).
Medline Abstract; PDB file 2IA8 and 2ICV

Vandemark AP, Kasten MM, Ferris E, Heroux A, Hill CP, Cairns BR.
Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.
Mol Cell. 27 817-28 (2007).
Medline Abstract; PDB file 2R0S , 2R0V,  2R0Y and  2R10
X4A, X26C
RapiData
Widboom PF, Fielding EN, Liu Y, Bruner SD.
Structural basis for co-factor-independant dioxygenase in vancomycin biosynthesis.
Nature 447 342-345 (2007).
Medline Abstract; PDB files 2NP9 and 2PG8
X29

Wang H, Peng M, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H.
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem J. 408 193-201 (2007).
Medline Abstract; PDB files 2QYK , 2QYL,  2QYM and  2QYN
X29
Wang H, Liu Y, Hou J, Zheng M, Robinson H and Ke H.
Structural insight into substrate specificity of phosphodiesterase 10.
Proc Natl Acad Sci U S A (2007).
Medline Abstract; PDB files 2OUN, 2OUP, 2OUQ, 2OUR 2OUS, 2OUU, 2OUV and 2OUY
X29
Wang H, Robinson H and Ke H.
The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10.
J. Mol. Biol. 371,  302-307 (2007).
Medline Abstract; PDB file  2PW3

Welch BD, Vandemark AP, Heroux A, Hill CP, Kay MS.
Potent D-peptide inhibitors of HIV-1 entry.
Proc Natl Acad Sci U S A. 104 16828-33 (2007).
Medline Abstract; PDB files 2R3C , 2R5B and  2R5D
X29
Zhang L, Shen J, Guarnieri MT, Heroux A, Yang K and Zhao R.
Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants.
Protein Sci.  2007 May 1; [Epub ahead of print]
Medline Abstract; PDB files 2P87 and 2P8R
X29
ZhangY,  Cao R,  Leon A,  Guo RT,  Krysiak K,  Yin F,  Hudock MP,  Mukherjee S,  Gao YG,  Robinson H,  Song Y,  No JH,  Hong W,  Morita C,  Wang AH-J,  Oldfield E.  
Bisphosphonates: Teaching Old Drugs with New Tricks 
To be Published   PDB files 2OPN  2OPM and 2OGD


2006
X29
Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI.
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.
Nat Struct Mol Biol.
  11 1029-30 (
2006).
Medline Abstract; PDB file 2HTH
X29
Buchko GW, Ni S, Robinson H, Welsh EA, Pakrasi HB, Kennedy MA.
Characterization of two potentially universal turn motifs that shape the repeated five-residues fold--crystal structure of a lumenal pentapeptide repeat protein from Cyanothece 51142.
Protein Sci. 11 2579-95 (2006).

Medline Abstract; PDB files 2F3L and 2G0Y

Buchko GW, Ni S, Robinson H, Welsh EA, Pakrasi HB, Kennedy MA.
Cloning, expression, crystallization and preliminary crystallographic analysis of a pentapeptide-repeat protein (Rfr23) from the bacterium Cyanothece 51142.
Acta Cryst. F62 1251-4 (2006).
Medline Abstract; PDB files 2F3L and 2G0Y
X12B
Copeland DM, Soares AS, West AH, Richter-Addo GB.
Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin.
J Inorg Biochem.; 100 1413-25 (2006).
Medline Abstract; PDB file 2FRF
X26C
Gallager DT, Smith NN, KIM SK, Heroux A, Robinson H and Reddy PT.
Structure of the Class IV Adenylyl Cyclase Reveals a Novel Fold.
J Mol Biol. (2006).
Medline Abstract; related PDB file 2FJT
X26C
Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT and Mitsuya H.
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.
J Med Chem.  49 5252-61 (2006).
Medline Abstract; PDB file 2HB3
X25
Han Q, Robinson H, Gao YG, Vogelaar N, Wilson SR, Rizzi M and  Li J.
Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase.
J Biol Chem. (2006)
Medline Abstract; PDB files 2HUF, 2HUI and 2HUU
X26C, X25
Huai Q, Sun Y, Wang H, Macdonald D, Aspiotis R, Robinson H, Huang Z and Ke H.
Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase.
J Med Chem.  49 1867-1873 (2006).
Medline Abstract; PDB files 2FM0 and 2FM5
X29
Kelly NB, Howard BR, Wang H, Robinson H, Sundquist WI and  Hill CP.
Implications for Viral Capsid Assembly from Crystal Structures of HIV-1 Gag(1)(-)(278) and CA(N)(133)(-)(278)(,).
Biochemistry.  45 11257-66 (2006).
Medline Abstract; PDB files 2GOL and 2GON
X29
Mao J,  Mukherjee S,  Zhang, Y,  Cao R,  Sanders JM,  Song Y,  Zhang Y,  Meints GA,  Gao YG,  Mukkamala, D,  Hudock, MP,  Oldfield E.
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
J.Am.Chem.Soc. 128 14485-14497 (2006).
Medline Abstract; PDB file 2I19
X12B
McDonough MA, Li V, Flashman E, Chowdhury R, Mohr C, Lienard BM, Zondlo J, Oldham NJ, Clifton IJ, Lewis J, McNeill LA, Kurzeja RJ, Hewitson KS, Yang E, Jordan S, Syed RS, Schofield CJ.
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Proc Natl Acad Sci U S A. 103  9814-9 (2006).
Medline Abstract; related PDB files 2GIM and 2G19

Meinke G, Bullock PA and Bohm A.
Crystal Structure of the simian virus 40 large T-antigen origin-binding domain.
J Virol.  80 4304-4312 (2006).
Medline Abstract; PDB file 2FUF
X26C
Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA and  Margulies DH.
Crystal structure of the murine cytomegalovirus MHC-I homolog m144.
J Mol Biol. 358(1) 157-71  (2006).
Medline Abstract; PDB files 1U58 and 1PQZ
X12C
 Ni S, Forouhar F, Bussiere DE, Robinson H and Kennedy MA.
Crystal structure of VC0702 at 2.0 A: conserved hypothetical protein from Vibrio cholerae.
Proteins. 63 733-41 (2006)
Medline Abstract; PDB file 1ZNO
X26C
Pena PV, Davrazou F, Shi X, Walter K, Verkhusha VV, Gozani O, Zhao R and Kutateladze TG.
Molecular mechanism of H3K4Me3 recognition by Plant Homeodomain of Inhibitor of Growth 2 tumor suppressor.
Nature
442 100-103 (2206).
Medline Abstract; PDB file native 2g6q
X26C
Reyes-Turcu FE, Horton JR, Mullally JE, Heroux A, Cheng X and Wilkinson KD.
The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin
Cell 124 1197-1195 (2006).
Medline Abstract; PDB files 2G43 and 2G45
X25,X29
Sanghani PC, Davis WI, Zhai L and Robinson H.
Structure-function relationships in human glutathione-dependent formaldehyde dehydrogenase. Role of Glu-67 and Arg-368 in the catalytic mechanism.
Biochemistry 18 4819-30 (2006).
Medline Abstract; PDB files 2FZE and 2FZW

Schubert HL, Hill CP.
Structure of ATP-Bound Human ATP:Cobalamin Adenosyltransferase.
Biochemistry 45 15188-96 (2006).
Medline Abstract; PDB file 2IDX 
X26C
Vandemark AP, Blanksma M, Ferris E, Heroux A, Hill CP, Formosa T
The Structure of the yFACT Pob3-M Domain, Its Interaction with the DNA Replication Factor RPA, and a Potential Role in Nucleosome Deposition.
Mol Cell.  22  363-74 (2006).
Medline Abstract; PDB files 2GCL and 2GCJ
X29
Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H.
Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.
J Biol Chem.  May 30 (2006)
Medline Abstract; PDB files 2H44, 2H40 and 2H42

Wang H, Peng MS, Chen Y, Geng J, Robinson H, Houslay MD, Cai J, Ke H.
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J. 408 193-201 (2007).
Medline Abstract; PDB files 2QYK, 2QYM and 2QYL

2005
X26C
Auperin TC, Bolduc GR, Baron MJ, Heroux A, Filman DJ, Madoff LC and Hogle JM.
Crystal Structure of the  N-terminal domain of group B Streptococcus Alpha C  Protein
J Biol Chem. 280 8245-52 (2005)
Medline Abstract; PDB file 1YWM
X29
Bitto E, Bingman CA, Robinson H, Allard STM, Wesenberg GE and Phillips Jr. GN
The structure at 2.5  Å resolution of human basophilic leukemia-expressed protein BLES03
Acta Cryst. F61 812-817 (2005)
Medline Abstract; PDB file
1ZTP
X29
Brown JH, Zhou Z, Reshetnikova L, Robinson H, Yammani RD, Tobacman LS and Cohen C.
Structure of the mid-region of tropomyosin: Bending and binding sites for actin.
Proc Natl Acad Sci U S A. 102 18878-83 (2005)
Medline Abstract; PDB file 2B9C

Chen F,  Sun H,  Zhang Y,  Mukkamala D and Oldfield E.
A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides.
J.Am.Chem.Soc.
127 12544-12554 (
2005).
Medline Abstract; PDB file 2EWG
X25
Forster A, Masters EI, Whitby FG, Robinson H and Hill CP.
The 1.9 A Structure of a Proteasome-11S Activator Complex and Implications for Proteasome-PAN/PA700 Interactions.
Mol Cell.  27 589-99 (2005)
Medline Abstract; PDB files 1YA7, 1YAU , 1Z7Q and 1YAR
X12C Han Q, Gao YG, Robinson H, Ding H, Wilson S and Li J.
Crystal structures of Aedes aegypti kynurenine aminotransferase.
FEBS J. 272 2198-206 (2005)
Medline Abstract; PDB files 1YIZ and 1YIY


Li F, Robinson H and Yeung ES.
Automated high-throughput nanoliter-scale protein crystallization screening.
Anal Bioanal Chem. 383 1034-41 (2005)
Medline Abstract; 
X26C
Loftin IR, Franke S, Roberts SA, Weichsel A, Heroux A, Montfort WR, Rensing C and McEvoy MM.
1.5 A Structure of apo-CusF residues 6-88 from Escherichia coli
Biochemistry 44 10533-40 (2005)
Medline Abstract; PDB file 1ZEQ
X26C Davison PA, Schubert HL, Reid JD, Iorg CD, Heroux A, Hill CP and Hunter CN.
Structural and Biochemical Characterization of Gun4 Suggests a Mechanism for Its Role in Chlorophyll Biosynthesis
Biochemistry 44 7603 - 7612 (2005)
Medline Abstract; PDB file 1Z3X and 1Z3Y
X12C
Safo MK, Zhao Q, Musayev FN, Robinson H, Scarsdale N, Wang AHJ and Archer GL.
Crystal Structures of the Blai Repressor from Staphylococcus Aureus and its Complex with DNA: Insights Into Transcriptional Regulation of the Bla and Mec Operons
J.Bacteriol. 187 1833-44 (2005)
Medline Abstract; PDB files 1SD4, 1SD6, 1SD7 and 1XSD
X29
Wang H, Liu Y, Chen Y, Robinson H and Ke H.
Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.
J Biol Chem.  280 30949-30955 (2005).
Medline Abstract; PDB file 1ZKL
X12B
Ye Q, Imriskova-Sosova I, Hill BC and Jia Z.
Identification of a Disulfide Switch in BsSco, a Member of the Sco Family of Cytochrome c Oxidase Assembly Proteins.
Biochemistry 44 2934-42 (2005)
Medline Abstract; PDB file 1XZO

2004
X12C
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA and Wedekind JE.
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.

Biochemistry 4313883-91 (2004)
Medline Abstract; PDB file 1U7H
X12C
Alam N, Stieglitz KA, Caban MD, Gourinath S, Tsuruta H and Kantrowitz ER.
240S Loop Interactions Stabilize the T State of Escherichia Coli Aspartate Transcarbamoylase.
J.Biol.Chem.
279 23302 (2004)
Medline Abstract; PDB file 1SKU
X26C

Gopalan G, He Z, Balmer Y, Romano P, Gupta R, Heroux A,  Buchanan BB, Swaminathan K and Luan S.
Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen.
Proc Natl Acad Sci U S A. 10113945-50 (2004)
Medline Abstract; PDB file 1U79
X25 X26C
Guan R, Malchiodi EL, Qian W, Schuck P, Mariuzza RA.
Crystal Structure of the C-Terminal Peptidoglycan-Binding Domain of Human Peptidoglycan Recognition Protein Ialpha
J.Biol.Chem.
279 31873-82 (2004)
Medline Abstract; PDB files 1SK3 and 1SK4
X26C
Gallagher DT, Monbouquette HG, Schroder I, Robinson H, Holden MJ, Smith NN.
Structure of alanine dehydrogenase from Archaeoglobus: active site analysis and relation to bacterial cyclodeaminases and mammalian mu crystallin.
J Mol Biol. 342 119-30 (2004)
Medline Abstract: PDB file 1OMO
X8C
Hauenstein S, Zhang CM, Hou YM, Perona JJ.
Shape-selective RNA recognition by cysteinyl-tRNA synthetase.
Nat Struct Mol Biol. 11 1134-41(2004)
Medline Abstract;  PDB file 1U0B
X12C
Huai Q, Wang H, Zhang W, Colman RW, Robinson H, Ke H.
Crystal Structure of Phosphodiesterase 9 Shows Orientation Variation of Inhibitor 3-Isobutyl-1-Methylxanthine Binding
Proc. Nat. Acad. Sci.USA
101 9624-9 (2004)
Medline Abstract;  PDB files 1TBM(2HD1)
X12C
Karthikeyan S, Zhou Q, Zhao Z, Kao CL, Tao Z, Robinson H, Liu HW, Zhang H.
Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-Carboxylate Deaminase Complexes: Insight Into the Mechanism of a Unique Pyridoxal-5'-Phosphate Dependent Cyclopropane Ring-Opening Reaction
Biochemistry 43 13328 (2004)
Medline Abstract;
  PDB files 1TZM, 1TZK, 1TYZ , 1TZJ and 1TZ2


Mao J, Gao YG, Odeh S, Robinson H, Montalvetti A, Docampo R, Oldfield E.
Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei.
Acta Crystallogr D60 1863-6 (2004)
Medline AbstractPDB file
2EWG
X12C

Ni S,  Robinson H, Marsing GC, Bussiere DE,  Kennedy MA.
Structure of 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase from Shewanella Oneidensis at 1.6A: Identification of Farnesyl Diphosphate Trapped in a Hydrophobic Cavity
Acta Crystallogr., D
60 1949 (2004)
Medline Abstract; PDB file 1T0A
X12B
Saxena S, Yuan P, Dhar SK, Senga T, Takeda D, Robinson H, Kornbluth S, Swaminathan K, Dutta A.
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Mol Cell. 15 245-58 (2004)
Medline Abstract; PDB file  1UII
X25
X8C
Phillips JD, Whitby FG, Warby CA, Labbe P, Yang C, Pflugrath JW, Ferrara JD, Robinson H, Kushner JP, Hill CP.
Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.
J Biol Chem. 279 38960-8. (2004)
Medline Abstract: PDB files 1TKL and  1TK1
X26C
Safo MK, Musayev FM, Hunt S, Di Salvo M, Scarsdale N, Schirch V.
Crystal Structure of the Pdxy Protein from Escherichia Coli
J. Bacteriol.  186 8074-8082 (2004)
Medline Abstract; PDB file 1TD2
X12B
Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC.
Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis.
J Biol Chem. 279 29320-4 (2004)
Medline Abstract; PDB file  1RCW
X26C
Smith N, Mayhew M, Holden MJ, Kelly H, Robinson H, Heroux A, Vilker VL, Gallagher DT.
Structure of C73G putidaredoxin from Pseudomonas putida
Acta Crystallogr. D60 816-22 (2004)

Medline Abstract; PDB file  1R7S
X12C
Woo EJ, Kim, YG, Kim, MS, Han, WD, Shin S, Robinson H, Park SY, Oh BH.
Structural Mechanism for Inactivation and Activation of Cad/Dff40 in the Apoptotic Pathway Molecular
Cell
14  531 (2004)
Medline Abstract;  PDB file  1V0D

2003
X12C
Fisher RD, Wang B, Alam SL, Higginson D, Rich R, Myszka D, Robinson H, Sundquist WI, and Hill CP.
Structure and ubiquitin binding of the ubiquitin interacting motif.
J. Biol. Chem. 278 28976-84 (2003)
 Medline Abstract;  PDB file 1O06
X26C
Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, and Ke H.
Crystal structure of DJ-1/RS and implication on familial Parkinson's disease.
FEBS Lett. 549 171-175 (2003)
Medline Abstract; PDB files 1PS4 and 1Q2U
X12C
Paaventhan P, Joseph JS, Seow SV, Vaday S, Robinson H, Chua KY, and Kolatkar PR.
A 1.7A structure of Fve, a member of the new fungal immunomondulatory protein family.
J. Mol. Biol. 332 461-470 (2003).
Medline Abstract; PDB file 1OSY
X12B

Sanghani PC, Robinson H, Bennett-Lovsey R, Hurley TD, and Bosron WF.
Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase).
Chem. Biol. Interact. 143-144, 195-200 (2003)
Medline Abstract;
X26C
Smith N, Mayhew M, Robinson H, Heroux A, Charlton D, Holden MJ and Gallagher DT.
Crystallization and phasing of alanine dehydrogenase from Archaeoglobus fulgidus.
Acta Crystallogr D59 2328-2331(2003)
Medline Abstract;

2002
X26C
Bateman K, Brownie E, Wolodko W and Fraser M
Structure of the Mammalian CoA Transferase from Pig Heart
Biochemistry 417 14455-14462, (2002)
 Medline Abstract; PDB file 1M3E
X26C
Hayashi I, Vuori K, Liddington RC.
The focal adhesion targeting (FAT) domain of focal adhesion kinase is a four-helix bundle that binds paxillin
Nat. Struct. Biol. 9 101-109 (2002)
Medline Abstract; PDB file 1K40
X12B
Sanghani PC, Robinson H, Bosron WF, Hurley TD.
Human glutathione-dependent formaldehyde dehydrogenase. Structures of apo, binary, and inhibitory ternary complexes.
Biochemistry 41 10778-86 (2002)
Medline Abstract; PDB files 1M6H, 1M6W and  1MA0
X12B
Singh SK, Kurnasov OV, Chen B, Robinson H, Grishin NV, Osterman AL, Zhang H.
Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities.

J Biol Chem. 277 33291-9 (2002)
Medline Abstract; PDB file 1LW7

2001-2000


Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X.
Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. 
Structure (Camb). 9 837-49 (2001)

Ko TP, Chen YK, Robinson H, Tsai PC, Gao YG, Chen AP, Wang AH and Liang PH.
Mechanism of product chain length determination and the role of flexible loop in Escherichia coli undecaprenyl pyrophosphate synthase
J. Biol. Chem. 276 47474-82 (2001)
Medline Abstract
PDB file 1JP3



Shipman LW, Li D, Roessner CA, Scott AI, Sacchettini JC.
Crystal structure of precorrin-8x methyl mutase.

Structure  9 587-96 (2001)



Martin G, Keller W, Doublie S.
Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP.

EMBO J. 19 4193-203 (2000)



Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM.
The structure and oligomerization of the yeast arginine methyltransferase, Hmt1. 
Nat Struct Biol. 12 1165-71 (2000)